A healthy heart is important right?

Most people would agree that a healthy heart is an important thing to have but not everybody is lucky enough to be born with a healthy heart. Development of the heart is very complex due to the fact that it goes through a lot of morphological (structural)  changes and all of the changes are controlled by genes. This makes gene expression very important. One of the important proteins that affects gene expression is chromodomain-helicase-DNA-binding protein 7 (CHD7). This protein is a large ATP dependent nucleosome remodeling protein which mean that this protein is responsible for helping with gene expression enhancers. When this gene is not working properly it affects transcription (part of turning genetic information into proteins) of the DNA and causes people to have CHARGE which causes a large amount of congenital heart defects.